The Super Cub was given a step-through design to make it easy to mount, and was engineered to be simple to operate, as well as agile enough to navigate the crowded streets of developing countries. By the time the CB750 made its debut in 1969, the Super Cub had been updated twice. In 1962, Honda brought the two-seater CA100 to market, and in 1966, Honda introduced the C50, which had a new overhead cam engine and a more scooter-like appearance. 

In 1981, the CT110, a trail-oriented version of the Super Cub, was created. This model had the largest and most potent Super Cub engine to date, a 105cc single-cylinder that cranked out 7.5 horsepower. A Super Custom version of the Super Cub 50 hit the roads in 1983, with an astounding fuel economy of 180 km/l (more than 420 mpg).

The 1991 Super Cub 50 Standard brought some cosmetic changes and the addition of an analog fuel gauge. In 1998, Honda built the C100 BIZ for Brazilian markets. This Super Cub had a larger fairing and a smaller rear wheel to make room for more storage space under the seat.

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